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A Short Route to Midazolam via Michael Addition to a Nitroolefin

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide A new approach to midazolam through Michael addition of 2-aminobenzophenone with a nitroolefin as a key step is reported. We devised a telescoped four-step synthesis using only one single protecting group, resulting in an excellent atom economy.

Source: Organic Process Research & Development

DOI: 10.1021/acs.oprd.5c00320

Authors: Lara Brunotte, Kai Oliver Donsbach, B. Frank Gupton, Till Opatz

Institutions: Johannes Gutenberg University Mainz, Virginia Commonwealth University

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

OpenAlex ID: W4415145987

FWCI:

Cites: 18

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