Work

Endometrial carcinosarcoma in a young female with absence of established risk factors: a case report

Year: 2025

Type: article

Abstract: Endometrial carcinosarcoma is a rare, aggressive uterine malignancy, usually affecting postmenopausal women with recognised risk factors such as prolonged unopposed oestrogen exposure, tamoxifen use, pelvic irradiation, or high BMI. We report a 21-year-old Chinese woman with no known risk factors who presented with persistent vaginal bleeding, anaemia, and lower abdominal pain. Investigations showed microcytic hypochromic anaemia, elevated CA125, CA153, CA199, and Human Epididymis Protein 4, and pelvic MRI revealed a malignant endometrial lesion with vaginal involvement and lymphadenopathy. Biopsy confirmed carcinosarcoma with grade 3 endometrioid carcinoma as the epithelial component. Multidisciplinary review recommended extensive laparoscopic hysterectomy with bilateral adnexectomy, lymphadenectomy, and omentectomy, followed by six cycles of paclitaxel-carboplatin chemotherapy. Histology confirmed the diagnosis, and two-year follow-up showed no recurrence; a postoperative vesicovaginal fistula was surgically repaired. This atypical case in a young, underweight woman without established risk factors challenges current epidemiological assumptions and emphasises the importance of broad diagnostic consideration, timely referral, and comprehensive management.

Source: Frontiers in Oncology

DOI: 10.3389/fonc.2025.1656841

Authors: Na Wei, Shifeng Bai, Donghui Kong, Xiaomin Wang, Xin Mi

Institutions: Tangshan People's Hospital, Liaoning Cancer Hospital & Institute, Beijing Children’s Hospital

Language: English

Topic: Endometrial and Cervical Cancer Treatments

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801