Work

Mn3O4-potentiated bifunctional hydrogel for mild temperature-controlled tumor ablation and osteogenesis

Year: 2025

Type: article

Abstract: Postoperative bone reconstruction after tumor resection remains challenging due to tumor recurrence and poor osteogenesis. Although photothermal scaffolds can ablate tumors (via high heat) and stimulate bone formation (via mild heat), balancing these effects is difficult—excessive heat damages tissue, while insufficient heat fails to eliminate tumors. Here, we develop an injectable Mn 3 O 4 -enhanced hydrogel (GM/OD/Mn 3 O 4 ) to address this. Mn 3 O 4 nanosheets, firstly synthesized via biomineralization, exhibit high photothermal efficiency and enzyme-mimetic activity (glucose oxidase/peroxidase-like). The hydrogel adapts to irregular defects and releases Mn 3 O 4 in acidic tumor microenvironments. Through catalytic cascades, it depletes ATP and inhibits heat shock proteins, overcoming tumor thermoresistance and enabling effective ablation at mild temperatures (43 °C). Lower NIR power (40 °C) further enhances osteogenesis. In vivo, the hydrogel suppresses tumor recurrence while promoting bone regeneration, offering a dual-functional strategy for postoperative bone repair. Addressing post-surgical bone tumor recurrence and insufficient osteogenesis, a smart Mn 3 O 4 - enhanced hydrogel is designed integrating photothermal conversion and dual-enzyme catalytic abilities. Tumor acidity-triggered Mn 3 O 4 release depletes ATP via glucose/H 2 O 2 cascade reactions, suppressing HSPs for apoptosis at 43 °C. Adjustable NIR power (40 °C) enhances osteogenesis. Injectable hydrogel validated for mild-temperature photothermal tumor ablation and bone regeneration in vivo . • Biomineralized Mn 3 O 4 nanosheets are of photothermal effect and dual-enzyme-like catalytic activity. • Mn 3 O 4 -enhanced hydrogel enable 43 °C tumor ablation via photothermal-catalytic synergy and HSP suppression. • Injectable hydrogel with NIR-controlled temperatures adapts to bone regeneration and tumor ablation. • Low-temperature (≤43 °C) photothermal stimulation safely promotes bone tumor therapy via dual HSP regulation.

Source: Bioactive Materials

DOI: 10.1016/j.bioactmat.2025.09.037