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Age- and Sex-dependent Effects of High-fructose, High-fat Diets on Small Bowel Inflammation and Hepatic Steatosis in F344 Rats

Year: 2025

Type: article

Abstract: Background/Aims: The liver and small bowel are closely interrelated, and their diet-induced metabolic dysfunction-associated steatotic liver disease (MASLD) may also be influenced by age and sex. Therefore, this study aims to investigate the effects of age and sex on hepatic steatosis and small bowel inflammation induced by a high-fructose and high-fat diet (HFHFD) in rats. Methods: ). Results: = 0.047) was significant, with the highest expression observed in aged female HFHFD rats. Conclusion: may contribute to MASLD in aged female rats.

Source: Journal of Neurogastroenterology and Motility

DOI: 10.5056/jnm24155