Work

Characterization and Radiation Response of Cancer-Associated Fibroblasts isolated from Glioblastoma

Year: 2025

Type: article

Abstract: Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis and strong resistance to radiotherapy. While cancer-associated fibroblasts (CAFs) are known in epithelial cancers, their presence in GBM has only recently been identified. In this study we isolated GBM-derived CAFs and confirmed their identity with specific markers. After irradiation (4-6 Gy), these CAFs showed no morphological or phenotypic changes and maintained viability, demonstrating radioresistance. The results indicate that CAFs may play a key role in GBM's resistance to treatment, underlining the need for further research on their role in radiotherapy failure.

Source: PubMed

DOI: 10.17912/micropub.biology.001810

Authors: Caroline Delmas, Elisabeth Cohen-Jonathan-Moyal, Catherine Seva

Institutions: Centre National de la Recherche Scientifique, Inserm, Centre de Recherches en Cancérologie de Toulouse, Institut universitaire du cancer de Toulouse Oncopole, Université de Toulouse

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4415147236

FWCI:

Cites:

Cited by:

Related to: