The feasibility of 3D bioprinting for bone regeneration: key challenges and future directions
Year: 2025
Type: article
Abstract: Three-dimensional (3D) bioprinting has emerged as a promising biofabrication strategy for bone regeneration, offering unprecedented control over the spatial distribution of cells, biomaterials, and bioactive cues. By enabling the production of anatomically customized grafts with microarchitectural complexity and biological functionality, bioprinting holds potential to overcome limitations associated with autografts, allografts, and synthetic bone substitutes. This review provides a comprehensive synthesis of recent advances in bioprinting technologies, bioink design, and recent in vitro and in vivo studies targeting bone tissue engineering. Despite encouraging preclinical outcomes, the field faces significant challenges, including limited mechanical performance, control over cellular microenvironments, lack of standardization, and trade-offs between printing resolution and scalability. Notably, no clinical trials have yet investigated bioprinted bone constructs, reflecting the translational hurdles that persist. We critically discuss these gaps and propose strategic directions. Collectively, this review underscores the feasibility of 3D bioprinting for bone regeneration while highlighting the key scientific and technical milestones needed to transition from bench to bedside.
Source: Regenerative Medicine
Authors: Thiago Domingues Stocco, Rafael Prado de Carvalho, Hugo Cesar Oliveira Silva, Taynara Soares de Melo Sousa
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Award: G1334996268
OpenAlex ID: W4415147279