Work

Risk factor analysis for deep vein thrombosis in children with acute hematogenous osteomyelitis

Year: 2025

Type: article

Abstract: OBJECTIVE: This study aims to explore the correlation between Acute Hematogenous Osteomyelitis (AHO) and Deep Venous Thrombosis (DVT) in children. It seeks to identify independent risk factors for DVT secondary to AHO, enhance understanding of the disease, and establish a predictive model to guide clinical practice. METHODS: was calculated through linear regression of P-values with the dependent variable. ROC curves were plotted, and AUC was recorded to evaluate model validity and reliability. RESULTS: = 0.413), and had strong predictive performance (AUC = 0.895). CONCLUSION: Age, peak levels of CRP/ESR/PCT/D-dimer, osteomyelitis severity (Lawson score), femoral involvement in osteomyelitis, and concurrent pneumonia were significantly associated with secondary deep vein thrombosis (DVT) in pediatric acute hematogenous osteomyelitis (AHO). Among these, age, peak D-dimer levels, and concurrent pneumonia were identified as independent risk factors for DVT in children with AHO. The current predictive model demonstrated good performance in this cohort, providing early warning for potential DVT risk in pediatric AHO patients. However, multicenter studies are needed to further validate its generalizability. Pediatricians may use this model to assess the necessity of DVT screening, reduce missed diagnoses, and initiate timely antithrombotic therapy to prevent adverse outcomes.

Source: BMC Musculoskeletal Disorders

DOI: 10.1186/s12891-025-09007-x