Work

Two G protein-coupled receptors bind ceramides in atherosclerosis progression: targets for a new therapeutic strategy

Year: 2025

Type: article

Abstract: A recent study published by Zhang et al. 1 in Nature suggested that the endogenous ceramide receptors cysteinyl leukotriene receptor 2 (CYSLTR2) and the pyrimidinergic receptor P2Y6 (P2Y6R) are potential novel targets for the treatment of atherosclerosis and related cardiovascular conditions beyond mainstream cholesterol control strategies. This new finding paves the way for another milestone in the emerging innovative search for novel atherosclerosis therapies.

Source: Signal Transduction and Targeted Therapy

DOI: 10.1038/s41392-025-02434-1

Authors: Yue Han, Peter Illes, Yong Tang

Institutions: Chengdu University of Traditional Chinese Medicine, Leipzig University

Language: English

Topic: Sphingolipid Metabolism and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,790