Work

Immunohistochemical and histopathological characteristics of adenomas and adenocarcinomas of Meibomian glands in dogs

Year: 2025

Type: article

Abstract: INTRODUCTION: This study aimed to provide a comprehensive histopathological and immunohistochemical analysis of Meibomian adenomas and adenocarcinomas. MATERIAL AND METHODS: A total of 80 tumours were included in the study: 33 adenomas and 47 Meibomian adenocarcinomas. Ki-67, cytokeratin-7 and von Willebrand factor antibodies were used for the immunohistochemical staining. RESULTS: Detailed characteristics of inflammatory infiltration depending on tumor type and damage to surrounding tissue by tumour cells are presented. A close correlation was found between the structure and intensity of blood vessel proliferation and the level of factor VIII expression. CONCLUSIONS: The presented detailed histopathological analysis, combined with the results of immunohistochemical studies, now allows for better treatment planning and prognosis assessment for patients.

Source: Folia Histochemica et Cytobiologica

DOI: 10.5603/fhc.108299