Year: 2025
Type: article
Abstract: Gnetofuran A, a newly extracted compound from Gnetum latifolium, possesses anti-inflammatory effects by inhibiting TNF-α activity.However, the function and mechanism of Gnetofuran A in osteoblast differentiation remain unknown.In this study, we found that Gnetofuran A enhanced osteoblast differentiation and upregulated the mRNA levels of osteogenic genes, including alkaline phosphatase (ALP) and osteocalcin (OC).Meanwhile, Gnetofuran A improved protein levels of Runt-related gene 2 (Runx2) and Osterix, the key transcription factors in osteoblast differentiation.Furthermore, we discovered that p38 MAPK signaling is involved in Gnetofuran A-induced osteoblast differentiation.A docking analysis showed the potential interaction between Gnetofuran A and p38.Taken together, our study provides a new biological function of Gnetofuran A and a therapeutic candidate for osteoporosis.
Source: Biomolecules & Therapeutics
Authors: Meiyu Piao, Lulu Yao, SeonJu Park, Namki Cho, Na-Lee Ka, Kwang Youl Lee
Institutions: Chonnam National University, Korea Basic Science Institute
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Awards: G3525594909, G4160125882, G8023347175
OpenAlex ID: W4415173217