Work

Roles of peripheral and central µ 1 -opioid receptors in the fentanyl-induced cardiorespiratory responses

Year: 2025

Type: article

Abstract: The cardiorespiratory responses to rapid intravenous injection of fentanyl have not been fully investigated. We demonstrate in this study that intravenous bolus injection of fentanyl triggers an immediate sustained apnea and subsequent respiratory depression without remarkable gender-difference in conscious rats. The immediate apnea is triggered by activating peripheral opioid receptors and the subsequent respiratory depression is mediated by activating central opioid receptors, in which µ1-opioid receptors play a key role.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00278.2025

Authors: Jianguo Zhuang, Xiuping Gao, Zikuan Chen, Shan Shi, Fadi Xu

Language: English

Topic: Neuropeptides and Animal Physiology

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Heart, Lung, and Blood Institute, National Institute on Drug Abuse, National Drug Abuse Treatment Clinical Trials Network

Awards: G3429436477, G3620396411, Mechanism and Countermeasure of Fentanyl-Induced Sudden Death, Mechanism and Countermeasure of Carfentanil-induced Respiratory Disorder and Death