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Upper Gastrointestinal Bleeding Secondary to Gastric Invasion by Diffuse Large B-cell Lymphoma

Year: 2025

Type: article

Abstract: Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma subtype. We present a case of an 80-year-old male with upper gastrointestinal bleeding (UGIB), ultimately diagnosed with DLBCL involving the liver, gallbladder, inferior vena cava, and stomach, leading to a large gastric ulcer. Despite initial suspicion of alcohol-related UGIB, imaging revealed multiple masses with extranodal lymphoma involvement. Endoscopic hemostasis was attempted but was complicated by tumor-induced neovascularization. This case highlights a rare cause of UGIB and underscores the challenges in diagnosis and management of malignancy-induced bleeding.

Source: Cureus

DOI: 10.7759/cureus.94594

Authors: Helen Paglia, Marco Noriega, Kinnari R Kher

Institutions: Memorial Health University Medical Center, Mount Auburn Hospital, Harvard University

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415181675