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Berberine-doped liposomes enhance factor IX mutant mRNA delivery for protein replacement therapy in hemophilia B

Year: 2025

Type: article

Abstract: Berberine-functionalized liposomes were developed for hemophilia B mRNA therapy. Six FIX mutant mRNAs were screened and complexed with berberine-doped liposomes, achieving efficient hepatic delivery and sustained FIX protein expression.

Source: RSC Pharmaceutics

DOI: 10.1039/d5pm00135h

Authors: Porkizhi Arjunan, Gokulnath Mahalingam, Harini Manogaran, Mohankumar Murugesan, Saravanabhavan Thangavel, Srujan Marepally

Institutions: Christian Medical College, Vellore, Institute for Stem Cell Biology and Regenerative Medicine

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415188400

FWCI:

Cites: 29

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