Year: 2025
Type: preprint
Abstract: The ability to modulate the tumor microenvironment emerges as a compelling strategy to stimulate antitumor immunity in solid tumors. In this context, innate immune cells, especially macrophages, are interesting targets for immunotherapies. Approaches, based on CRISPR, to delete specific suppressive molecules in these cells might lead to antitumor immunity depending on the type of tumors, since their tumor microenvironment can be diverse. This correspondence aims to discuss published animal models and stimulate research in this critical subject for the improvement of immunotherapies aiming on macrophages. New therapeutic strategies, including epigenetic modifications to stabilize the proinflammatory phenotypes of these cells, are underscored.
Institution: Universidade do Estado do Rio de Janeiro
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4415190154
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