Work

Effect of Influenza Vaccination on Mortality and Heart Failure Hospitalization in Heart Failure Patients

Year: 2025

Type: article

Abstract: Background: The association of influenza vaccination and heart failure (HF) hospitalization and mortality in Thai HF patients is unknown. Objective: We wished to investigate associations between receiving an influenza vaccine and all-cause death or HF hospitalization in HF patients. Methods: We retrospectively reviewed medical records from two large tertiary-care centers in Thailand (Ramathibodi Hospital and Maharaj Nakorn Chiang Mai Hospital) with newly diagnosed heart failure between 2013 and 2020 in an outpatient clinic. We examined the relationship between influenza vaccination and outcomes in a propensity-adjusted model. Results: Of 588 patients, 181 (31%) received an influenza vaccination. During a median follow-up of 57 months, influenza vaccination was associated with a 56% reduction in the risk of HF hospitalization or death (HF hospitalization or all-cause death: HR: 0.44; 95% CI: 0.31–0.63; p < 0.001) in an unadjusted analysis. After propensity score adjustment, influenza vaccination, however, was not associated with a reduced risk of all-cause death but was associated with a reduced risk of HF hospitalization (ATE: 3.06 years; 95% CI: 0.14 to 5.98; p = 0.04). Conclusions: In patients with HF, influenza vaccination was not associated with a reduced risk of the composite of all-cause death or HF hospitalization after adjustment for confounders.

Source: Vaccines

DOI: 10.3390/vaccines13101055

Authors: Chatpetch Maneesopit, Arintaya Phrommintikul, Jackrapong Bruminhent, Ammarin Thakkinstian, Teerapat Yingchoncharoen

Institutions: Mahidol University, Ramathibodi Hospital, Chiang Mai University

Language: English

Topic: Heart Failure Treatment and Management

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,258