Evaluation of polyhydroxyalkanoates-based blends for sustainable drug delivery device component manufacturing
Year: 2025
Type: article
Abstract: The suitability of different polyhydroxyalkanoate (PHA) blends for the replacement of polypropylene (PP) in Novo Nordisk’s injection pen application was evaluated. PHA blends were analysed, each with varying ratios of PHAs, including poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV), poly-3-hydroxybutyrate-co-3-hydroxyhexanoate (PHBH), and poly-3-hydroxybutyrate-co-4-hydroxybutyrate (P3HB4HB), with variable talc compositions. The crystallisation kinetics, secondary crystallisation and mechanical properties were examined through differential scanning calorimetry and tensile testing. Lastly, a life cycle analysis (LCA) and an environmental risk assessment (ERA) were performed, and the influence of different crystallisation rates on processing cycle time was studied. The Avrami model was applied to isothermal crystallisation of the blends, it revealed that an equilibrated balance between semi-crystalline and amorphous PHAs, with shorter hydrocarbon chains and a small talc addition, accelerated crystallisation. Tensile tests indicated a higher strength and lower creep behaviour for blends that have a ratio close to 1:1. In addition, blends containing PHBH exhibited lower tensile strains and toughness but a larger Young’s modulus. LCA results demonstrated a carbon footprint reduction of 4% with optimised composition. The blend containing 55 wt% PHBV and 45 wt% PHBH with a low amount of talc exhibited the best potential based on all measured parameters, which was confirmed by successful moulding into a high-precision component.
Source: Results in Engineering
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,940
OpenAlex ID: W4415199158