Year: 2025
Type: article
Abstract: Membraneless organelles, also known as biomolecular condensates, lack a surrounding membrane and are formed through liquid‐liquid phase separation (LLPS). This process enhances reaction efficiency by compartmentalizing and concentrating reactants. Coacervates, a class of condensates, provide promising synthetic alternatives for improving enzymatic reactions. This review examines how LLPS enhances reaction efficiency in both natural and artificial systems, explores the design principles of coacervate‐based artificial organelles employed in (bio)catalysis, and discusses challenges and future directions for leveraging LLPS in catalysis.
Source: ChemSystemsChem
Language: English
Topic: RNA Research and Splicing
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,030
Awards: G1267406209, G3020285831, G3340144160, Unraveling the Molecular Mechanisms of Membraneless Organelles Using Peptide-Based Systems to Enhance Catalytic Function, G4941345466, Ciências da Vida para um Futuro Saudável e Sustentável, Microbiologia Molecular, Estrutural e Celular - – Instituto de Tecnologia Química e Biológica António Xavier, G6380322609, Peptide-PARC: Programmable Coacervation of short peptides into Artificial Regulatory Compartments, A microfluidics-based approach to create catalytic coacervates, G8347645112
OpenAlex ID: W4415200111