Binding studies of Ruthenium(II) polypyridyl complexes with DNA isolated from spinach extract
Year: 2025
Type: article
Abstract: Despite significant medical advancements, the need for a more effective and less toxic chemotherapeutic agent remains a pressing challenge in modern medicine. This study investigates the binding interactions of ruthenium polypyridyl complexes with spinach DNA samples, aiming to understand their potential as therapeutic agents and in other fields. The binding interactions between [Ru(LL)3]2+, (L- bpy-bipyridyl and dmbpy-dimethyl bipyridyl) complexes, and the DNA from spinach(Spinacia oleracea) were analyzed by UV-visible spectroscopy and emission graphs. The binding constants were determined by the Benesi-Hildebrand method. Both complexes exhibit significantinteraction with the spinach DNA,as indicated by the binding constants in a range of 105 M-1. The results suggest potential applications of these complexes in biomedical and plant biotechnological fields. However, further in-depth mechanistic studies are warranted.
DOI: 10.71336/jabs.1469
Authors: Lohidas Anitha Mabel Gaflin Shelty, Thangadurai Sumitha Celin, George Allen Gnana Raj
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4415200792