Work

Theoretical analysis of MWCNT and MXene/High-k pH BioFET sensors for biomedical applications

Year: 2025

Type: article

Abstract: In this paper, a theoretical analysis and comparative study of pH BioFET sensor designs using silicon/silicon dioxide (Si/SiO2), multi-walled carbon nanotube (MWCNT), and MXene/High-k dielectric materials is conducted. Being able to measure pH accurately and quickly is crucial in various fields, like clinical diagnostics, environmental study, food quality control, and industrial process management. Traditional sensing methods often have limitations in terms of sensitivity, selectivity, portability, and continuous observing. The incorporation of advanced materials, specifically carbon nanotubes and Ti3C2Tx MXene, into biosensor designs leads to improved sensing capacities, primarily attributed to their elevated surface-to-volume ratios, heightened sensitivity, and inherent biocompatibility. The study details the structural aspects of each BioFET device and employs a mathematical model to analyze their performance. Simulation results demonstrate that the MXene/High-k device exhibits superior electrical properties, including higher drain current, and transduction sensitivity, making it highly promising for advanced pH sensing applications compared to conventional Si/SiO2 and MWCNT-based sensors.

Source: Scientific Reports

DOI: 10.1038/s41598-025-19805-x

Authors: Gaurav Dhiman, Abhinandan Routray

Institutions: Dehradun Institute of Technology University, Manipal Academy of Higher Education

Language: English

Topic: Analytical Chemistry and Sensors

Subfield: Bioengineering

Field: Chemical Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,690

Funder: DIT University