Work

Heparanase2 inhibits the growth of gallbladder cancer by regulating the VEGF/VEGFR pathway

Year: 2025

Type: article

Abstract: Heparanase 2 (Hpa2), a homolog of heparinase, lacks the conventional heparinase activity associated with heparin degradation. However, it exhibits a greater affinity for heparin sulfate (HS) compared to heparinase. In our study, overexpression of Hpa2 significantly inhibited the viability, migration, and invasion of gallbladder cancer cells, both in vivo and in vitro. Moreover, this inhibitory effect of Hpa2 was reversed upon administration of agonists targeting the VEGF/VEGFR pathway. These findings suggest that Hpa2 overexpression may impede the growth of NOZ cells, potentially through modulation of the VEGF/VEGFR signaling pathway.

Source: Discover Oncology

DOI: 10.1007/s12672-025-03696-5

Authors: Dengyi Cao, Jiawei Chen, Shaobo Zhou, Jie Tang, Zixiang Liu, Zixiang Zhang

Institutions: First Affiliated Hospital of Soochow University, The Second Affiliated Hospital of Bengbu Medical College

Language: English

Topic: Cholangiocarcinoma and Gallbladder Cancer Studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,690