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Preanalytical mystery: falsely elevated intact parathyroid hormone due to sampling from a grafted forearm

Year: 2025

Type: article

Abstract: Spurious elevations in intact parathyroid hormone (iPTH) can lead to unnecessary interventions. We describe a dialysis patient who developed unexpectedly high iPTH concentrations months after total parathyroidectomy with forearm autotransplantation (TPTX-AT). Blood samples had been collected from the grafted forearm, resulting in falsely elevated iPTH values. Once the sample was collected from the non-grafted arm, iPTH concentrations normalized. This case highlights the importance of sampling site awareness in laboratory diagnostics and demonstrates how implementing a simple laboratory information system (LIS)-based protocol can prevent misinterpretation.

Source: Biochemia Medica

DOI: 10.11613/bm.2025.031002

Authors: Yu-Wei Tseng, Chun-Chieh Yeh, Che-Yi Chou, Si-Yu Chen, Tze-Kiong Er

Institutions: Asia University Hospital, Asia University, Asia University

Language: English

Topic: Clinical Laboratory Practices and Quality Control

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Asia University Hospital, Asia University