Year: 2025
Type: article
Abstract: Six previously undescribed sesquiterpenoids, aurantiophilanes A–F (1–6), along with six identified analogues (7–12), were isolated from the fungus Aspergillus aurantiobrunneus. Among these, compounds 1 and 3 were identified as highly oxygenated eremophilane sesquiterpenoids, with compound 1 featuring a rare ketone functional group at C-1. The structures of all compounds were unambiguously elucidated using comprehensive spectroscopic analyses, including HRESIMS, NMR, and UV spectroscopy, supplemented by electronic circular dichroism (ECD) analyses and single-crystal X-ray diffraction. All identified compounds were evaluated for immunosuppressive activity; none showed significant effects at concentrations up to 40 µM.
Source: Molecules
Authors: Xueying Deng, Mengsha Wei, Yuyi Zheng, Yong Shen, Alan Bao, Mengru Yu, Chunmei Chen, Qin Li, Hucheng Zhu
Institution: Huazhong University of Science and Technology
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,258
Awards: G2161153591, G7784949446, G826289394
OpenAlex ID: W4415213687