Work

Multifunctional antibacterial and antioxidant hydrogel based on modified sodium alginate and green-synthesized Ag NPs for wound dressing applications

Year: 2025

Type: article

Abstract: Wound healing is a complex biological process that requires effective materials to restore skin integrity. The objective of this study was to develop a bio-nanocomposite hydrogel with antibacterial, antioxidant, and hemostatic functions for wound healing applications. Sodium alginate (SA) was sequentially modified through dialdehyde and dicarboxylate functionalization and co-polymerized with acrylamide (AAm) and acrylic acid (AA) using potassium persulfate (KPS) as the initiator and N, N -methylene bisacrylamide (MBA) as the crosslinker. Silver nanoparticles (Ag NPs) were green-synthesized using Calendula officinalis (CO) extract and incorporated into the hydrogel. The prepared hydrogel showed a swelling capacity of 6700 % within 2 h and underwent controlled biodegradation under physiological conditions. Antibacterial tests demonstrated inhibition zones of 27 mm against Escherichia coli and 28 mm against S. aureus . The hydrogel also displayed 73 % antioxidant activity, 98 % cell viability in HFF-2 cells, a hemolysis index below 2 %, and a hemostatic index of 25 %. These results indicate that the hydrogel has potential for supporting wound healing through its combined antibacterial, antioxidant, and hemostatic properties.

Source: Chemical Engineering Journal Advances

DOI: 10.1016/j.ceja.2025.100915

Authors: Shabnam Tahmasebi, Reza Mohammadi

Institution: University of Tabriz

Language: English

Topic: Wound Healing and Treatments

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,050