Work

Bacterial agent, antibiotic resistance profile and predictors of urinary tract infection among pregnant women attending antenatal care in Ethiopia

Year: 2025

Type: article

Abstract: • Overall prevalence of UTI was 14.9%. • E. coli was followed coagulase-negative staphylococci, S. aureus , and Proteus species were common bacterial isolates. • The sensitivity of gram-negative isolates to ceftazidime and norfloxacin was high. • Vancomycin and ceftriaxone caused significant sensitivity in Gram-positive isolates. • Women’s history of catheterization, and history of UTI were the identified factors of UTI. Urinary tract infections (UTIs) are common globally, impacting living quality and creating financial and medical difficulties. They're a concern in community and hospital settings. The purpose of the study was to assess the bacteriological profile, risk factors, and antibiotic susceptibility patterns of urinary tract infections in pregnant women attending antenatal care in East Wallaga, Ethiopia. Institutional-based cross-sectional research was carried out among pregnant women. The Kirby-Bauer disk diffusion technique was used to identify bacterial profiles and evaluate them for antibiotic sensitivity. A 95% CI was used to determine whether a p-value was statistically significant if it was less than 0.05. In this study, the total prevalence of urinary tract infections was 14.9% (95% CI: 11.0–18.8%) (n = 44/296). Most of the isolated organisms were gram-negative (61.4%). E. coli was the most predominant isolate (40%). Eighty-seven percent of the bacterial isolates were ampicillin resistant. Multidrug resistance was seen in 77.3% of the isolated bacteria. History of catheterization and history of UTI were identified as significant predictors of UTI. In pregnant women, bacterial isolates from the current investigation indicated an alarming amount of antibiotic resistance. Therefore, it's critical to identify the drug-susceptibility pattern of the causative agents of UTIs and diagnose them early and routinely.

Source: IJID Regions

DOI: 10.1016/j.ijregi.2025.100787