Work

High resolution detection of stationary and evolving two-dimensional current source density within neuronal microcircuits

Year: 2025

Type: article

Abstract: We developed a novel methodology to analyze electrophysiological recordings obtained from hippocampal slices with a high-density microelectrode array. Current generators are separated into sinks and sources, and disjoint components are identified within active loci in the hippocampal substructures. A center of mass is obtained from each component, which can be tracked in time at near-cell resolution, revealing a putative route of transfer of information that can be quantitated with high spatiotemporal definition.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00098.2025

Authors: W. P. Karel Zapfe, Isabel Romero-Maldonado, Rafael Gutiérrez

Institutions: Instituto Politécnico Nacional, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Universidad Nacional Autónoma de México

Language: English

Topic: Neuroscience and Neural Engineering

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: hybrid

Funder: Consejo Nacional de Ciencia y Tecnología

OpenAlex ID: W4415217141

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Cites: 35

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