Pulmonary artery size on computed tomography associates with mean pulmonary artery pressure and mortality
Year: 2025
Type: article
Study design: Observational Study
Abstract: RATIONALE: Pulmonary artery (PA) dilation on computed tomography (CT) has been associated with moderate-to-severe -pulmonary hypertension (PH) using outdated diagnostic criteria. The association between PA size and mean PA pressure (mPAP) in mild PH and the prognostic implications of PA dilation remain unclear. OBJECTIVES: To investigate associations between PA size, mPAP, and survival in subjects without significant lung disease aside from PH. METHODS: PA size on CT was measured for individuals with group 1 or 2 PH and matched controls in the Pulmonary Vascular Disease Phenomics cohort. Outcomes included mPAP on right heart catheterization (RHC) and time to heart and/or lung -transplantation or death. MEASUREMENTS AND MAIN RESULTS: A total of 691 subjects were included, with 595 undergoing RHC. PA diameter and PA:aorta ratio demonstrated significant association with mPAP (ρ = 0.557 and 0.564, respectively). Size increased incrementally from no PH to mild PH to moderate-severe PH for PA diameter (27.64 [95% CI, 17.64-37.64] mm to 30.65 [95% CI, 18.99-42.31] mm to 36.00 [95% CI, 22.46-49.54] mm) and PA:aorta (0.89 [95% CI, 0.53-1.24] to 0.99 [95% CI, 0.63-1.35] to 1.19 [95% CI, 0.60-1.78]). PA diameter and PA:aorta demonstrated good discrimination of mPAP >20 mm Hg (area under the curve: 0.834 and 0.816, respectively). Transplant-free survival decreased across the continuum of PA diameter and PA:aorta (P <.001). Adjusted hazard ratio of third versus first quartile values was 2.36 (95% CI, 1.58-3.54) for PA diameter and 2.24 (95% CI, 1.52-3.30) for PA:aorta. CONCLUSIONS: In subjects without significant lung disease outside of PH, PA size on CT was associated with increased mPAP and decreased transplant-free survival across the spectrum of PH severity and demonstrated modest diagnostic discriminatory ability using updated hemodynamic criteria.
Authors: Tyler J Couch, Gerald J Beck, Erika Berman-Rosenzweig, J Jeffrey Carr, Serpil C Erzurum, Robert P Frantz, Paul M Hassoun, Nicholas S Hill, Evelyn M Horn, Jason K Lempel, Jane A Leopold, Hui Nian, David N Ray, Franz P Rischard, Kevin T Schwalbach, James G Terry, Anna R Hemnes, the PVDOMICS Study Group
Institutions: Vanderbilt University, Vanderbilt University Medical Center, Cleveland Clinic, Westchester Medical Center, New York Medical College, Columbia University, Cleveland Clinic Lerner College of Medicine, Mayo Clinic, Johns Hopkins University, Tufts Medical Center, Weill Cornell Medicine, Brigham and Women's Hospital, Harvard University, University of Arizona
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4415218155