Year: 2025
Type: article
Study design: Case Report
Abstract: Atopic dermatitis (AD) is a chronic and relapsing skin condition that often begins in childhood but can persist or worsen into adulthood, significantly impacting quality of life. We present the case of a 41-year-old woman with long-standing, treatment-resistant AD, unresponsive to various systemic therapies including corticosteroids, methotrexate, thalidomide, and cyclosporine. Despite some control with methotrexate, she experienced frequent flares and side effects. This report highlights the clinical challenges and therapeutic considerations in managing chronic, treatment-resistant AD. It also shows the potential of targeted biologic therapies as more effective and better-tolerated alternatives. Early recognition of treatment resistance is crucial to improving patient outcomes.
Source: Cureus
DOI: 10.7759/cureus.94667
Authors: María Laura Alvarado Fernández, María Luisa Alvarado Mora, Fiorella Apuy Rodríguez, Jessica Arias, Paula Vanegas Navarro
Institution: Universidad de Costa Rica
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4415218667