Year: 2025
Type: article
Abstract: A halogen atom transfer‐enabled radical fluoroalkyl‐thiolation of unactivated alkenes is developed employing fluoroalkyl iodides, TMEDA‐ligated zinc thiolates. Notably, the aryldiazonium salts are utilized as the promoter in the three‐component reaction, providing a powerful tool for simultaneous construction of CRf and CS bonds across the CC bond. Moreover, direct thiolation of fluoroalkyl iodides without alkene gives the two‐component reaction products. Mechanistic studies support that the interaction between diazonium salt and zinc thiolate plays a crucial role in the transformations.
Source: Advanced Synthesis & Catalysis
DOI: 10.1002/adsc.70162
Authors: Yanchuang Zhao, Yule Xie, Aman Ullah, Ying Bai, Shao‐Fei Ni, Xinxin Shao
Institutions: Hangzhou Normal University, Shantou University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4415218989