LINC01871 is exclusively expressed in T and NK cells and is highly induced upon CD4+ T cell activation
Year: 2025
Type: article
Abstract: T cell activation and is predominantly located in the cytoplasm. The anti-inflammatory cytokine TGF-β was found to suppress its expression. Silencing LINC01871 led to a modest decrease in IL-2 secretion. Notably, LINC01871 expression was highly specific to NK cells and T cells in several cross-tissue single cell RNA-seq atlases. These data suggest that LINC01871 is specifically expressed in T and NK cells and may contribute to T cell-mediated immunity in humans.
Source: iScience
Authors: Ubaid Ullah Kalim, Ankitha Shetty, Amogh Ranade, Olof Rundquist, Inna Starskaia, Kedar Batkulwar, Tommi Välikangas, António G.G. Sousa, Antti Hurme, Venla Kumpulainen, Miro Viitala, Sakari Kosola, Sini Junttila, Omid Rasool, Laura L. Elo, Sanjeev Galande, Riitta Lahesmaa
Institutions: Åbo Akademi University, University of Turku
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,240
Funders: Juvenile Diabetes Research Foundation United States of America, European Commission, Academy of Finland, Suomen Kulttuurirahasto, Jane ja Aatos Erkon Säätiö, Novo Nordisk, Päivikki ja Sakari Sohlbergin Säätiö, Turun Yliopisto, Sigrid Juséliuksen Säätiö, Novo Nordisk Fonden, Biocenter Finland, Suomen Syöpärekisteri, Horizon 2020 Framework Programme, European Research Council, Horizon 2020, H2020 Marie Skłodowska-Curie Actions
Awards: G1218519190, G1372623014, G1488931364, G1969949363, G2263502968, G263359668, European Network Linking Informatics and Genomics of Helper T cells in Tissues, G3728645740, G4039138905, G4279378766, G4303067336, New regulators of human regulatory T cell differentiation and function, G5124512152, G5241901595, G5636713125, G5781633740, G6837154255, G691688778, G7407552710, Immunoregulation and Therapeutic Precision in Rheumatoid Arthritis, G8219537402, G86959952, G8697803143, G9000152695
OpenAlex ID: W4415220561