Work

Resolution of pancytopenia in a dog infected with Bartonella rochalimae in association with antibiotic therapy

Year: 2025

Type: article

Abstract: Fever, non‐regenerative anaemia and leukopenia were documented in a 7‐year‐old, entire, male Akita Inu dog. The serum biochemistry and urinalysis were unremarkable. Tests for infectious agents were negative, except for SNAP 4Dx seropositive for Anaplasma phagocytophilum or A. platys . PCR for Anaplasma spp. was negative. There was mild improvement after initial administration of doxycycline; however, pancytopenia developed after 1 month. Echocardiography showed a mild thickening of the aortic and pulmonary valves. Bone marrow cytology showed an erythroid and myeloid hypoplasia. Blood culture was negative, but PCR of peripheral blood was positive for Bartonella rochalimae . Amoxicillin‐clavulanic acid plus enrofloxacin was started, and 5 days later, the condition improved. Pancytopenia associated with B. rochalimae was diagnosed. The treatment was continued for 10 months. Progressive improvement in haematological parameters was observed, and both antibiotics were discontinued after 10 months, when Bartonella PCR in peripheral blood became negative. The dog remains stable to date.

Source: Veterinary Record Case Reports

DOI: 10.1002/vrc2.70236

Authors: Clàudia Viñeta, Javier Martínez‐Caro, Edward B. Breitschwerdt, Josep Pastor, Xavier Roura

Institutions: Universitat Autònoma de Barcelona, North Carolina State University

Language: English

Topic: Bartonella species infections research

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,480