Generation of induced pluripotent stem cell line UJSi005-A from developmentally delayed schizophrenic patients
Year: 2025
Type: article
Abstract: Schizophrenia, a chronic mental health condition, is characterized by abnormalities in perception, emotions and behavior. We successfully generated induced pluripotent stem cells (iPSCs) from the peripheral blood mononuclear cells (PBMCs) of a patient with schizophrenia and neurodevelopmental delay who responded well to olanzapine therapy. The iPSCs exhibited a normal karyotype, expressed markers of undifferentiated human pluripotent stem cells (hPSCs), and differentiated into the three germ layers in vivo.
Source: Stem Cell Research
Authors: Xuan Xu, Bing Xue, Dingqi Zhang, Yupeng Wang, Bonan Chen, Zhenghua Shan, Wenzhuo Zhao, Tianxiao Qiu, Jing Sun, Shengying Qin
Institutions: Jiangsu University, Shanghai Jiao Tong University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,360
Funders: National Natural Science Foundation of China, Jiangsu University, China Postdoctoral Science Foundation, Science and Technology Commission of Shanghai Municipality, Department of Science and Technology of Sichuan Province, Shanghai Jiao Tong University, Shanghai Aerospace Science and Technology Innovation Foundation, National Key Research and Development Program of China, Fundamental Research Funds for the Central Universities
OpenAlex ID: W4415225327