Year: 2025
Type: article
Study design: Case Report
Abstract: BACKGROUND: COVID-19 has an uncharacteristic course in immunodeficient patients, often contributing to diagnostic and therapeutic difficulties and the reactivation of latent infections. OBJECTIVE: To describe the clinical course and therapeutic outcomes in immunocompromised patients with persistent COVID-19 who were found to have concurrent cytomegalovirus (CMV) reactivation, and to assess the potential impact of anti-CMV therapy on SARS-CoV-2 clearance. MATERIAL AND METHODS: Four different cases of COVID-19 pneumonia and immune disorders were evaluated, and the intended effect was not achieved, despite multidirectional treatment aimed at SARS-CoV-2. This prompted further virological research to investigate the features of CMV reactivation. RESULTS: Multidirectional treatment of COVID-19 in immunodeficient patients did not contribute to viral eradication. In all patients, high CMV viremia was observed with the use of ganciclovir/valganciclovir, which suppressed CMV replication and contributed to the elimination of SARS-CoV-2. CONCLUSIONS: This case series highlights the complex relationship between SARS-CoV-2 and CMV, emphasizing the need for a comprehensive virological evaluation of persistent COVID-19 cases. As the global medical landscape has grappled with the evolving challenges of the pandemic, incorporating such multifaceted clinical insights remains paramount.
Source: Przeglad Epidemiologiczny
DOI: 10.32394/pe/211664
Institution: Pomeranian Medical University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4415229061
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