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Invasive Meningococcal Disease in a Patient With Complement 7 Deficiency

Year: 2025

Type: article

Abstract: ABSTRACT Neisseria meningitidis can cause invasive meningococcal disease (IMD). Individuals with primary complement deficiencies are at a higher risk of developing IMD. However, cases of IMD associated with complement deficiency have rarely been reported in Japan. In this case, a 35‐year‐old Japanese man presented with fever and a spreading skin rash. Blood culture identified N. meningitidis serogroup B. The patient was treated with antibiotics and fully recovered. Genetic analysis revealed a deficiency in complement component 7. This case highlights that IMD can occur in young, otherwise healthy individuals, some of whom may have underlying complement deficiency.

Source: Journal of General and Family Medicine

DOI: 10.1002/jgf2.70075

Authors: Hiroaki Nishioka, Kazuki Maegawa, Shigeo Hara

Institution: Kobe City Medical Center General Hospital

Language: English

Topic: Bacterial Infections and Vaccines

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,600