Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Phyllodes tumors (PTs) are rare interstitial tumors that account for <1% of all breast tumors. The best surgical option for PTs is controversial, particularly in patients with giant PTs. Methods: This retrospective single-center study selected patients with giant borderline/malignant PT (>10 cm) treated in our center between January 2017 and July 2022. We conducted a detailed analysis and identified rare cases. Survival analysis was performed using the Kaplan-Meier method. Results: This study included 24 patients with PTs >10 cm, including 15 borderline and nine malignant PTs. Among these patients, 12 underwent extended lumpectomy and 12 underwent mastectomy at initial diagnosis. All patients were followed up for a median of 49.8 months. Local recurrence occurred in 50% of the patients who underwent lumpectomy, whereas none of the patients who underwent mastectomy and achieved R0 resection had recurrence. Several special cases are described in detail separately. Conclusion: Mastectomy may reduce local recurrence rates in patients with giant borderline/malignant PTs of the breast. Complete tumor resection and clean margins are the most important factors in controlling local recurrence.
Source: Frontiers in Oncology
Authors: Chang Chen, Ying Xu, Xin Huang, Yan Lin, Qiang Sun
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4415234708