Work

Case Report: Expanding the spectrum of renal involvement in adult-onset still’s disease: a case of focal proliferative glomerulonephritis and ischemic nephropathy

Year: 2025

Type: article

Abstract: Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder characterized by high spiking fever, evanescent rash, and arthritis. Renal involvement in AOSD is uncommon but clinically significant, with varied manifestations such as AA amyloidosis, thrombotic microangiopathy (TMA), and collapsing glomerulopathy. In this case report, we presented a unique instance of a 28-year-old female with AOSD complicated by both focal proliferative glomerulonephritis (FPGN) and ischemic nephropathy-two rare renal manifestations confirmed via renal biopsy. The patient exhibited persistent fever, joint pain, and proteinuria, which were unresponsive to initial antimicrobial treatment but showed marked improvement following corticosteroid and immunosuppressive therapy. This case expands the known spectrum of renal involvement in AOSD and underscores the importance of prompt identification and individualized therapy. We also provide a comparative analysis of reported renal pathologies in AOSD to enhance understanding and guide management strategies.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2025.1609256

Authors: Lina Zhang, Yan Song, Suxia Wang, Shengguang Li

Institutions: Peking University International Hospital, Chinese PLA General Hospital, Peking University First Hospital

Language: English

Topic: Autoimmune and Inflammatory Disorders Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801