Year: 2025
Type: article
Abstract: Objective To explore the blocking effect of a barrier nasal mask composed of bionic nasal hair combined with a blocking gel on allergen particles in a 1:1 3D-printed nasal cavity model and to provide new ideas for the clinical prevention and treatment of allergic rhinitis. Methods A 1:1 scale 3D-printed nasal cavity model was constructed, and dust-free paper was placed at specific anatomical locations within the model. The experimental group was defined as those wearing a nasal mask, whereas the control group did not wear a nasal mask. A simple breathing bag was used to simulate normal respiration, and a pneumatic nebulizer was employed to introduce stained Artemisia annua pollen. The simulated breathing experiments were conducted for 15 min and 30 min. The degree of staining on the dust-free paper in both groups was observed and scored. Results At 15 min, the median (25th, 75th percentiles) total scores for all anatomical sites in the nonblocking group and blocking group were 3 (2, 4) and 0 (0, 1), respectively (Z = −9.094, p < 0.001). At 30 min, the total scores of the two groups were 4 (2, 5) and 1 (0, 2), respectively (Z = −9.062, p < 0.001). Additionally, the comparison of scores at all other individual anatomical sites revealed p < 0.001. Conclusion This barrier nasal mask can effectively reduce pollen particle deposition at various anatomical sites in the nasal cavity. The crossover test using the same model verified the reliability of its blocking efficacy, which suggests that it is a potential innovative intervention for the prevention of allergic rhinitis.
Source: Frontiers in Medicine
Authors: Yan Zhang, Na Lu, Yuxiang Zhao, Jinping Wang
Institution: Shaanxi Provincial People's Hospital
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4415237281