Work

Photobiomodulation in fibroblasts: from light to healing through molecular pathways, omics and artificial intelligence

Year: 2025

Type: article

Abstract: Photobiomodulation (PBM), a non-invasive therapy that uses non-ionizing light in the visible to near-infrared spectrum, has proven to be a promising strategy for promoting tissue repair and regeneration. PBM has its roots in heliotherapy and low level light therapies and works by activating specific molecular pathways in the target cells. Among these, fibroblasts play a central role in mediating wound healing responses. This article provides a comprehensive overview of the mechanisms of action of PBM, focusing on the effects on fibroblast biology, including modulation of proliferation, migration and extracellular matrix remodeling. Recent advances in omics technologies and artificial intelligence (AI) provide new tools to unravel the complexity of PBM-induced signaling and optimize therapeutic protocols. By integrating data-rich approaches and systems-level analysis, this work highlights the potential of PBM as a precision-guided regenerative modality and underscores the need for further translational studies to support its clinical application.

Source: Frontiers in Bioengineering and Biotechnology

DOI: 10.3389/fbioe.2025.1675619

Authors: Sarassunta Ucci, Eugenio Caradonna, Anna Aliberti, Andrea Cusano

Institutions: University of Sannio, Centro Diagnostico Italiano

Language: English

Topic: Laser Applications in Dentistry and Medicine

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801