Novel Discorhabdin Derivatives from Antarctic Sponges of the Genus Latrunculia: Expanding the Chemical Diversity of Polar Marine Natural Products
Year: 2025
Type: article
Abstract: In this study, three Antarctic sponges of the genus Latrunculia were investigated, leading to the isolation of five unreported pyrroloiminoquinone alkaloids along with the known metabolite (+)-debromodiscorhabdin A (3). Three of the new metabolites were brominated, while the other two were found to have a C-5/C-8 sulfur bridge and a C-2/N-18 bridge. Three of the metabolites were shown to have a phenyl ketone substituent on C-14, not previously reported for discorhabdin derivatives. The cytotoxicity against the A549 cell lines was studied and compounds 1–4 showed activity of 4.3, 1.8, 1.0, and 23.9 µM, respectively, while no inhibition was found for 5 and 6.
Source: Marine Drugs
DOI: 10.3390/md23100401
Authors: Sam Afoullouss, Stine S. H. Olsen, Sydney Morrow, Ezequiel Cruz Rosa, Kaley Geu, Nerida G. Wilson, Bill J. Baker
Language: English
Subfield: Biotechnology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,499
Awards: G1483802566, BIOPROSPECTING THE FUNGAL METABOLOME FOR ANTI-FUNGAL NATURAL PRODUCTS, Collaborative Research: The Chemical Ecology of Shallow-water Marine Macroalgae and Invertebrates on the Antarctic Peninsula, National High Magnetic Field Laboratory Renewal 2023-2027, Natural Product Derived Inhibitors of ESKAPE Pathogens
OpenAlex ID: W4415239121