Work

Blastoids for Modeling Early Embryonic Development: Application to Domestic Livestock

Year: 2025

Type: review

Abstract: Recent advances in technologies that replicate specific aspects of embryogenesis in vitro by using stem cells have opened new frontiers in our understanding of the earliest steps of mammalian development and creation of promising novel assisted reproductive technologies (ARTs). We begin by summarizing the widely used ARTs in improving animal reproduction. We then explore current progress in deriving embryo-based stem cells from livestock species and highlight the latest breakthroughs in blastoid generation. Furthermore, we examine the potential applications of blastoids in domestic livestock and discuss key challenges and future directions for advancing blastoid models that closely mimic natural embryonic development.

Source: Annual Review of Animal Biosciences

DOI: 10.1146/annurev-animal-111523-102012

Authors: Hao Ming, Jun Wu, Zongliang Jiang

Institutions: University of Florida, Institute of Food and Agricultural Sciences, The University of Texas Southwestern Medical Center

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

OpenAlex ID: W4415243734

FWCI: 0.104

Cites: 98

Cited by: 1

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