Work

Research progress in techniques related to pressurized intraperitoneal aerosol chemotherapy (PIPAC)

Year: 2025

Type: article

Abstract: Pressurized intraperitoneal aerosol chemotherapy is a novel method for intraperitoneal chemotherapy, with favorable feasibility, safety, and tolerability. The preliminary results are encouraging, and numerous clinical researches of this therapy are ongoing. To further optimize drug distribution, penetration depth, and therapeutic efficacy of PIPAC, basic and clinical studies have also been carried out, such as modification of nebulizer, rotational PIPAC, hyperthermic PIPAC, and electrostatic precipitation of PIPAC. In addition to the investigation of chemotherapeutic agents, the potential of non-chemotherapeutic drugs for intraperitoneal aerosolized drug delivery has been examined, including anti-adhesion drugs, nanoparticles, nucleic acid drugs, and oncolytic viruses. This paper offers a comprehensive overview of the technological advancements associated with PIPAC.

Source: Holistic Integrative Oncology

DOI: 10.1007/s44178-025-00190-4

Authors: Qiming Fan, Renjie Li, Zifeng Yang, Yong Li

Institutions: Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Southern Medical University

Language: English

Topic: Intraperitoneal and Appendiceal Malignancies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Natural Science Foundation of China, Natural Science Foundation of Guangdong Province, Guangdong Provincial People's Hospital