A rare case of concurrent smoldering waldenström macroglobulinemia and myelodysplastic syndrome
Year: 2025
Type: preprint
Study design: Case Report
Abstract: Smoldering waldenström macroglobulinemia (SWM) and Myelodysplastic Syndrome (MDS) are two common diseases in clinical hematology, but they have distinct clinical and pathological characteristics, and SWM and MDS rarely occur simultaneously. This case report presents a very rare patient with both SWM and MDS, illustrates the confusion and challenges in diagnosing a patient presenting with IgM gammopathy, bone marrow dysplasia and anemia. This case reviews the coexistence WM and MDS/AML, as well as the coexistence of monoclonal gammopathy of undetermined significance (MGUS) and MDS is reviewed. ABSTRACTWaldenström macroglobulinemia (WM) is a low-grade non-Hodgkin lymphoplasmacytic lymphoma of the bone marrow, characterized by production of monoclonal immunoglobulin M (IgM) protein.Smoldering waldenström macroglobulinemia (SWM) is asymptomatic and exhibits an increased risk of progression to WM. Myelodysplastic syndrome (MDS) arises from blood cancer in the hematopoietic stem cell compartment, featuring dysplastic changes in bone marrow and blood cells, along with cytopenias, including anemia, neutropenia, or thrombocytopenia.Both are common conditions in clinical hematology, but they exhibit distinct clinical and pathological characteristics.Also, the co-occurrence of WM and MDS is extremely rare, linited to a few case reports.This case report presents a patient with both SWM and MDS, and discusses the clinical manifestations, diagnosis, differential diagnosis, and molecular genetic characteristics.Additionally, it reviews the coexistence of WM and MDS/AML, as well as the coexistence of MGUS and MDS.
Authors: yuan wang, shuai tan, Wanling Sun
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4415245166
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