Treatment intervals with first-generation anti-vascular endothelial growth factor drugs: evaluating the unmet need in a real-world neovascular age-related macular degeneration national database
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: To evaluate treatment intervals at 12/24 months following initiation of anti-VEGF therapy and to characterise the clinical profile of neovascular AMD (nAMD) patients achieving extended treatment intervals (≥12 and ≥16 weeks). METHODS: National, retrospective, real-world study using data from the validated web-based Fight Retinal Blindness (FRB!) registry. Treatment-naive nAMD eyes managed with approved first-generation intravitreal VEGF inhibitors (ranibizumab, aflibercept 2 mg) and followed for at least 12 months were included. A subanalysis was conducted on eyes receiving a number of injections within range of a treat and extend (TAE) regimen at 12 and 24 months. RESULTS: A total number of 1278/557 treatment-naïve nAMD eyes within the TAE range category completed the required follow up at 12/24 months. At 12 months, 39.3% of eyes remained on ≤Q8W, 22.5% >Q8W- < Q12W, 29.1% ≥Q12W- < Q16 and 9.1% ≥Q16W. At 24 months, the distribution was 35.4%, 17.6%, 28.3% and 18.7%, respectively. Mean VA change was not significantly different between groups at both 12 months (≤ Q8W: +4.7, Q8-Q12: +3.5, Q12-Q16: +6.1, ≥Q16W: +4.8 letters) and 24 months (≤Q8W: +5.8, Q8-Q12: +3.7, Q12-Q16: +4.1, ≥Q16W: +3 letters). The percentage of visits with active lesions was similar across groups at both time points, indicating consistent disease control. CONCLUSIONS: Despite receiving a number of injections within a TAE range, a substantial proportion of eyes failed to achieve extended treatment intervals at 12 and 24 months (61.8% and 52.9%, respectively). These results underscore the significant unmet therapeutic need in the management of nAMD with currently approved first-generation anti-VEGF agents.
Source: Eye
Authors: Javier Zarranz-Ventura, Gonzaga Garay-Aramburu, Pilar Calvo, Miguel Angel Zapata, Carolina Arruabarrena, Pablo Arnáiz, Paula García-Lunar, Laura Sararols-Ramsay, on behalf of the FRB SPAIN study group, Javier Zarranz-Ventura, Ruben Martin-Pinardel, Marc Figueras-Roca, Aina Moll-Udina, Jordi Izquierdo-Serra, Alba Serrano, Jose Grau, Carolina Bernal-Morales, Sofia Batllé-Ferrando, Sonia Marias-Perez, Socorro Alforja, Ricardo P. Casaroli-Marano, Gabriel Londoño, Maximiliano Olivera, Alba Gomez, Karim Bañon, Cynthia Rethati, Rafael Montejano-Milner, Gabriel Liaño-Sanz Díez de Ulzurrun, Miguel Angel Zapata, Helena Brosa, Laura Sánchez-Vela, Marta Garrido, José García-Arumí, Ana Fernández-Hortelano, Jesús Zarallo-Gallardo, Rosario Cobo-Soriano, Inmaculada Lozano-Escobar, Paula Moreno-Martín, Pilar Calvo, Jorge Sánchez, Martín Puzo, María Pilar Ruiz-Del-Tiempo, Oscar Ruiz-Moreno, Gonzaga Garay-Aramburu, Maria Teresa Arrazola Berrizbeitia, Arantza Larrauri-Arana, Angela Gómez-Moreno, David Rodríguez-Feijoo, Enrique Diaz-de-Durana-Santa-Coloma, Maialen Aldazabal-Echeveste, Zuriñe del-Barrio-Lopez-de-Ipiña, Irene Herrero-Díaz, Maximino José Abraldes López-Veiga, María Lidia Gómez Conde, María José Rodríguez-Cid, María Isabel Fernández Rodríguez, Pablo Fernández Varela, Jacobo González Guijarro, Muxima Acebes García, Sonia Aparicio Sanchís, Jonathan Cacelliere Fernández, Marta Belmonte Grau, Marta S. Figueroa, Esther Ciancas, Julio José Gonzalez-López, Carles Barnes, Esther Cilveti, Stefani Carrillo, Lucia Miguel-Escuder, Jose Mª Ruiz Moreno, Rocío Vega-González, María García Zamora, Ignacio Flores-Moreno, Eva Salinas Martínez, Francisco Javier Lavid de los Mozos, Alfredo García-Layana, Manuel Saenz de Viteri, Elena Alonso, Patricia Fernandez-Robredo, Sergio Recalde, Jose Juan Escobar-Barranco, Manel Fernandez-Bonet, Begoña Pina-Marín, Xavier Valldeperas, Laura Broc-Iturralde, Ferran Vilaplana Mira, Sandra Gómez Sánchez, Pamela Campos Figueroa, Lluis Arias-Barquet, Estefanía Cobos, Daniel Lorenzo Parra, Carmen A. Rodríguez-Fernández, Francisco Javier Ascaso-Puyuelo, Ana Honrubia Grijalbo, Ana Boned Murillo, María Dolores Díaz Barreda, Guillermo Pérez Rivasés, Ismael Bakkali El Bakkali, Nuria Oliver, Nerea Castro Casal, Cristóbal Quintero González, Sara Rubio Cid, Daniel Velázquez-Villoria, Cesar Azrak Haskour, Alvaro Piñero Sánchez, Roberto Gallego-Pinazo, Marta Cholbi, Rosa Dolz-Marco, Mónica Asencio Duran, Nélida Muñoz Sanz, Ester Carreño, Nestor Ventura, Luis J. Castillón Torre, Pablo Catalán Muñoz, María Eugenia Tena Sempere, María de Fátima Álvarez Gil, Purificación Piñas García, María Eugenia Mantrana Bermejo, Saturnino Gismero-Moreno, Ana Chinchurreta Capote, Ana Belén González Escobar, Juan Angel Moreno Gutierrez, Pablo Carnota-Méndez, Carlos Méndez-Vázquez, Carlos Torres-Borrego, Francisco Rodríguez Hurtado, Jesús Ramón García-Martínez, Alejandro Fonollosa Calduch, Jose Antonio Sanchez, Lucia Galletero, Alba Parrado-Carrillo, Isaac Alarcón-Valero, Teresa Diago, Adrián Hernández-Martínez, Jesús Pareja Esteban, María Angeles Espiñeira Periñan, Mariano Rodríguez-Maqueda, Magdalena Sotomayor Toribio, Marta Rodríguez-Núñez, Ana Campo Gesto
Institutions: Hospital Clínic de Barcelona, Fundació Clínic per a la Recerca Biomèdica, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, University of the Basque Country, BioCruces Health research Institute, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón, Vall d'Hebron Hospital Universitari, Hospital Universitario Príncipe de Asturias, Roche (Spain), Hospital General de Granollers, Hospital Universitario del Henares, Hospital de Cruces, Hospital Provincial de Conxo, Hospital Universitario de La Princesa, Hospital Universitario Ramón y Cajal, Hospital de Sant Joan Despí Moisès Broggi, Hospital Universitario Puerta de Hierro Majadahonda, Hospital Quirón Torrevieja, Clinica Universidad de Navarra, Hospital Universitari Germans Trias i Pujol, Bellvitge University Hospital, Hospital Clínico Universitario Lozano Blesa, Complejo Hospitalario Universitario de Ferrol, Hospital Universitario del Vinalopó, Oftalmología Vistahermosa SL, Hospital Universitario La Paz, Hospital Universitario Fundación Jiménez Díaz, Hospital San Juan de Dios del Aljarafe, Hospital Costa del Sol, Hospital Universitario Virgen de las Nieves, Hospital Del Mar, Hospital de La Ribera, Clínica Rementería, Hospital Universitario Virgen del Rocío
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,590
Funder: Roche
OpenAlex ID: W4415246994