Work

Deterministic Modeling of Muller’s Ratchet Effect in Populations Evolving in an Environment of Finite Capacity

Year: 2025

Type: article

Abstract: We study how small harmful mutations spread in populations that reproduce asexually. This process is known as Muller’s ratchet—it means that even though these mutations are damaging, they can still build up over generations. To explore this, we use a mathematical model that describes how such mutations move through a population living in an environment with limited resources. We model Muller’s ratchet deterministically using differential equations, incorporating modifications that account for extinction risk of small mutation classes. We analyze two modifications: a published cutoff modification and a more flexible exponential modification. We show that the exponential modification better matches stochastic simulations over specific parameter ranges.

Source: Applied Sciences

DOI: 10.3390/app152011090

Authors: Wojciech Łabaj, Jarosław Gil, Mateusz Kania, Ewa Lach, Agnieszka Szczęsna, Andrzej Polański

Institution: Silesian University of Technology

Language: English

Topic: Evolution and Genetic Dynamics

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,896

Funder: Silesian University of Technology