Work

Synthetic Preparation of the Macrocyclolipopeptide Dysoxylactam A for Potent P-glycoprotein Inhibition

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide In 2019, the cyclolipopeptide dysoxylactam A was isolated and reported to be a potent inhibitor of the drug efflux pump P-glycoprotein and demonstrated the ability to reverse multidrug resistance in cancer cell lines. Herein, we report a reliable and flexible route toward dysoxylactam A, which features key transformations such as the Paterson 1,2- anti aldol reaction, an sp 3 -sp 3 Fu–Suzuki coupling, asymmetric allylation, and the Corey–Nicolaou macrolactonization. All the data obtained on the synthesized natural product matched those of the authentic material.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c01765

Authors: Petros Danielsen Siapkaras, Karoline Hanssen, Eirik Johansson Solum, Marius Aursnes

Institutions: Norwegian University of Life Sciences, Norwegian University of Science and Technology, Nord University

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500