Clinical use of DermaBind TL/FM as a wound covering for hard-to-heal wounds of various aetiologies: a case series
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: The purpose of this retrospective case series is to describe real-world clinical experience with DermaBind TL or FM, (HealthTech Wound Care, US), a dehydrated full-thickness placental membrane intended for homologous use as a protective wound covering in wounds of various aetiologies that failed to heal with standard of care (SoC). Method: This retrospective observational, uncontrolled case series collected data from healthcare providers in the US. Eligible cases were patients, ≥18 years of age, with hard-to-heal wounds who received DermaBind TL or FM after having completed a minimum of four weeks of SoC without evidence of wound improvement. Data collected included patient demographics, wound characteristics and wound size. Results: The cases of 27 patients encompassing 36 wounds were included. The average age of patients included was 72.4 years (range: 37–101 years). The majority of wounds were pressure ulcers (63.9%), followed by diabetic foot ulcers (19.4%) and venous leg ulcers (8.3%). Wound onset was, on average, 29 weeks prior to the first graft application with the placental membrane, and the average wound size was 34cm 2 . Graft applications occurred weekly, with an average duration of treatment of 6.7 weeks. The observed average percentage surface area reduction across the 36 wounds was 69.1% (range: –17.6–100%). No adverse events were reported by the provider across all patient cases. Conclusion: These observations describe the clinical use of DermaBind as a wound covering material consistent with its homologous natural protective role. Larger, prospective studies are warranted to further investigate its clinical use. The authors would like to stress that this non-randomised, retrospective uncontrolled case series was used to describe findings, such as number of grafts applied, observed percentage of surface area reduction and graft wasted, and not to demonstrate efficacy.
Source: Journal of Wound Care
Authors: Jason Mendivil, Abby E McMahon, Oludayo Toby Ojelade, Kelly Hobson, Melissa Marballie, Sandry Alvarez, Vivian Adu-Aboagye, Georgia Chiamba, Donovan Gowdie, Willie E Landrum II, Ahlam Alzindani, Habeeb Yazdani, Gabriel Petty, Marie-Chantale Simard, Douglas Schmid, Jessica Meadors
Institution: Aptitude Health (United States)
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4415259785