Work

Low microRNA-338-3p expression drives cutaneous squamous cell carcinoma progression and predicts poor prognosis

Year: 2025

Type: article

Abstract: Objectives To explore the clinical significance and influence of miR-338-3p in cSCC. Methods The content of miR-338-3p in cSCC was quantified using qRT-PCR. Prognostic relevance of miR-338-3p in cSCC was evaluated via Kaplan-Meier curve analysis. Functional roles of miR-338-3p in cSCC cell behavior were assessed through MTT assays, transwell assays. Results miR-338-3p was low-expressed in cSCC, with levels linked with lymph node metastasis, TNM stage, and disease progression. Statistically, miR-338-3p was a predictor of poor prognosis in cSCC. Functionally, miR-338-3p restoration weakened cSCC cellular viability and metastatic potential in vitro . Conclusions In cSCC, miR-338-3p exhibited downregulated expression, which suppressed cell viability, migratory behaviors, and invasive abilities. It has potential as a predictor for prognosis and a therapeutic target in cSCC.

Source: Turkish Journal of Biochemistry

DOI: 10.1515/tjb-2025-0173

Authors: Dongshuo Ji, Dayong Chen, Shaocong Lv, Liling Shen

Institutions: Beijing Hospital, Changchun University of Chinese Medicine, Shandong University

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $848