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3C. 3-Ketosteroid receptors in GtoPdb v.2025.3

Year: 2025

Type: article

Abstract: Steroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [75, 221, 3]) are nuclear hormone receptors of the NR3 class, with endogenous agonists that may be divided into 3-hydroxysteroids (estrone and 17β-estradiol) and 3-ketosteroids (dihydrotestosterone [DHT], aldosterone, cortisol, corticosterone, progesterone and testosterone). For rodent GR and MR, the physiological ligand is corticosterone rather than cortisol. Clinically-used drugs interacting with the 3-ketosteroid receptors include testosterone (AR), methylprednisolone (GR), eplerenone (MR), and medroxyprogesterone (PR).

Source: IUPHAR/BPS Guide to Pharmacology CITE

DOI: 10.2218/gtopdb/f98/2025.3

Authors: Derek Cain, Nancy Weigel, Marc Tetel, Carol A. Sartorius, Jennifer K. Richer, Robert H. Oakley, Carol A. Lange, Sean Hartig, Sandra L. Grimm, Peter Fuller, Dean P. Edwards, John Cidlowski, Morag J. Young

Institutions: National Institutes of Health, Baylor College of Medicine, Wellesley College, University of Minnesota, Hudson Institute, Hudson Institute of Medical Research, Baker Heart and Diabetes Institute

Language: English

Topic: Estrogen and related hormone effects

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415266511

FWCI:

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