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Calcium- and sodium-activated potassium channels (KCa, KNa) in GtoPdb v.2025.3

Year: 2025

Type: article

Abstract: Calcium- and sodium- activated potassium channels are members of the 6TM family of K channels which comprises the voltage-gated KV subfamilies, including the KCNQ subfamily, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 6 or 7TM) and the Ca2+- and Na+-activated SK subfamily (nomenclature as agreed by the NC-IUPHAR Subcommittee on Calcium- and sodium-activated potassium channels [144]). As for the 2TM family, the pore-forming a subunits form tetramers and heteromeric channels may be formed within subfamilies (e.g. KV1.1 with KV1.2; KCNQ2 with KCNQ3).

Source: IUPHAR/BPS Guide to Pharmacology CITE

DOI: 10.2218/gtopdb/f69/2025.3

Authors: Richard Aldrich, K. George Chandy, Stephan Grissmer, George A. Gutman, Leonard K. Kaczmarek, Aguan D. Wei, Heike Wulff

Institutions: Stanford University, University of California, Irvine, Universität Ulm, Yale University, Washington University in St. Louis, University of California, Davis

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

OpenAlex ID: W4415266516

FWCI: 0.301

Cites:

Cited by: 1

Related to: 10