Recent advances in microfluidics and bioelectronics for three-dimensional organoid interfaces
Year: 2026
Type: article
Abstract: Organoids offer a promising alternative in biomedical research and clinical medicine, with better feature recapitulation than 2D cultures. They also have more consistent responses with clinical results when compared to animal models. However, major challenges exist in the longevity of culture, the reproducibility of organoid properties, and the development of non-disruptive monitoring methods. Recent advances in materials and microfabrication methods, such as 3D printing and compressive buckling, have enabled three-dimensional (3D) interfaces of microfluidics and bioelectronics to manipulate and monitor these biological models in exciting ways. These advanced systems have great potential for applications in drug delivery, personalized medicine, and disease modeling. We conclude with important future considerations to generate longevity using further technological development in organoid and spheroid models.
Source: Biomicrofluidics
DOI: 10.1063/5.0306055
Authors: Caroline Ferguson, Mei Shao, Yan Li, Yi Zhang, Xueju Wang
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Awards: Multifunctional 3D Bioelectronic and Microfluidic Hybrid Systems for Online Monitoring, Regulation, and Vascularization of Organoids, G8736683996, CAREER: Implantable multimodal bioelectronics for high-performance gastrointestinal monitoring and modulation, A Wireless, Multimodal Neural Probe for Simultaneous Membrane-Free Neurochemical Sampling and Neuropharmacology, Engineering Extracellular Vesicles of Human Brain Organoids for Stroke Therapy
OpenAlex ID: W4415270626