A giant multinodular plexiform schwannoma of the brachial plexus: Differential diagnosis, multidisciplinary treatment, and surgical approach
Year: 2025
Type: article
Study design: Case Report
Abstract: Background: Plexiform schwannoma (PS) is a rare variant of schwannoma, characterized by multifascicular, intraneural, and multinodular growth. Its differential diagnosis from schwannomas, neurofibromas, and plexiform neurofibromas is essential for optimal treatment planning. Case Description: This article presents the case of a 53-year-old male who experienced stinging pain and weakness in his left hand, alongside muscle atrophy in the thenar eminence. Magnetic resonance imaging revealed a brachial plexus tumor, which was surgically resected. Histological analysis confirmed a brachial plexus schwannoma (the World Health Organization [WHO] grade I). After 3 years, the tumor recurred, leading to a two-stage surgical intervention. Histological examination identified it as a PS (the WHO grade I). Adjuvant tomotherapy achieved good long-term tumor control. Conclusion: This case highlights the difficulties in histopathological diagnosis and multidisciplinary management in achieving favorable outcomes, minimizing neurological risks.
Source: Surgical Neurology International
Institution: IRCCS Ospedale San Raffaele
Language: English
Subfield: Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4415276993